Latest Articles on Coronaviruses
- A clinical pharmacokinetic drug-drug interaction study between dextromethorphan and emvododstat, a potent anti-SARS-CoV-2 dihydroorotate dehydrogenase inhibitor Tue, 06 Jun 2023 06:00:00 -0400
CONCLUSION: Emvododstat appears to be a strong CYP2D6 inhibitor. No drug-related treatment emergent adverse effects (TEAEs) were considered to be severe or serious. - Aneurysms involving the coronary arteries in a neonate with neurofibromatosis 1 Tue, 06 Jun 2023 06:00:00 -0400
Aneurysmal coronary artery disease (ACAD) has been reported rarely in patients with neurofibromatosis type 1 (NF1), mostly in adults. We report on a female newborn affected by NF1 with ACAD disclosed during investigation for an abnormal prenatal ultrasound along with a review of the previously reported cases. The proposita had multiple café-au-lait spots and had no cardiac symptoms. Echocardiography, and cardiac computed tomography angiography confirmed aneurysms on the left coronary artery,... - Gastrointestinal manifestations of long-term effects after COVID-19 infection in patients with dialysis or kidney transplantation: An observational cohort study Mon, 05 Jun 2023 06:00:00 -0400
CONCLUSION: Different from patients with non-chronic kidney disease, there was a high prevalence of GI manifestations of Long-COVID in dialysis-dependent patients and KT recipients. An appropriate long-term follow-up in these vulnerable populations after COVID-19 infection is possibly necessary. - Neuroimaging mechanisms of acupuncture on functional reorganization for post-stroke motor improvement: a machine learning-based functional magnetic resonance imaging study Mon, 05 Jun 2023 06:00:00 -0400
CONCLUSION: Feature ROIs identified by machine learning can predict the classification of stroke patients with different motor improvements, and the FC between these ROIs with other brain regions is decreased. Acupuncture can modulate the bilateral cerebral hemispheres to restore abnormal FC via different targets, thereby promoting motor recovery after stroke. - Differences in the Cell Type-Specific Toxicity of Diamond Nanoparticles to Endothelial Cells Depending on the Exposure of the Cells to Nanoparticles Mon, 05 Jun 2023 06:00:00 -0400
CONCLUSION: We confirmed the presence of a relationship between the toxicity of diamond nanoparticles and the level of cell exposure to nanoparticles and the nanoparticle surface. The results of the study give new insights into the conditioned toxicity of nanomaterials and their use in biomedical applications. - A Cause of Heart Failure: Corona-Cameral Fistula Mon, 05 Jun 2023 06:00:00 -0400
No abstract - Genomics Research with Undiagnosed Children: Ethical Challenges at the Boundaries of Research and Clinical Care Sun, 04 Jun 2023 06:00:00 -0400
CONCLUSION: Our results suggest that parents of undiagnosed children seeking enrollment in genomic diagnosis research are at risk of a form of therapeutic misconception - in this case, diagnostic misconception. These findings indicate the need to examine the processes and procedures associated with this research in order to appropriately communicate and balance the potential burdens and benefits of study participation. - Instrument-assisted soft tissue mobilization versus myofascial release therapy in treatment of chronic neck pain: a randomized clinical trial Sat, 03 Jun 2023 06:00:00 -0400
CONCLUSION: This study showed insignificant differences between groups. However, we did not use a control group, indicating that the improvement in outcomes may not have been caused by the intervention. - Dual targeting Salinomycin-loaded smart nanomicelles for enhanced accumulation and therapeutic outcome in breast cancer Fri, 02 Jun 2023 06:00:00 -0400
Salinomycin is a polyether compound that exhibits strong anticancer activity and is known as the cancer stem cell inhibitor that reached clinical testing. The rapid elimination of nanoparticles from the bloodstream by the mononuclear phagocyte system (MPS), the liver, and the spleen, accompanied by protein corona (PC) formation, restricts in vivo delivery of nanoparticles in the tumor microenvironment (TME). The DNA aptamer (TA1) that successfully targets the overexpressed CD44 antigen on the... - Body composition and physical activity of university students during COVID-19 lockdowns Fri, 02 Jun 2023 06:00:00 -0400
[Purpose] Behavioral restrictions during the corona virus disease 2019 (COVID-19) pandemic may have affected the physical activity levels of college students. We aimed to characterize the body composition and physical activity of college students during these behavioral restrictions. [Participants and Methods] The body composition (height, weight, body mass index, body fat mass, body fat percentage, total body muscle mass, free-fat muscle index [FFMI], and fat mass index [FMI]), physical...